科研亮點
科學日報專題報導香港分部主任錢培元教授領銜的深海生物研究成果
Genomic secrets of scaly-foot snail from hydrothermal vents: Laying foundation for potential solutions provided by deep-sea creatures
Journal Reference:
Jin Sun, Chong Chen, Norio Miyamoto, Runsheng Li, Julia D. Sigwart, Ting Xu, Yanan Sun, Wai Chuen Wong, Jack C. H. Ip, Weipeng Zhang, Yi Lan, Dass Bissessur, Tomo-o Watsuji, Hiromi Kayama Watanabe, Yoshihiro Takaki, Kazuho Ikeo, Nobuyuki Fujii, Kazutoshi Yoshitake, Jian-Wen Qiu, Ken Takai, Pei-Yuan Qian. The Scaly-foot Snail genome and implications for the origins of biomineralised armour. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-15522-3
科學日報專題報導香港分部主任錢培元教授領銜的活性物質的研究成果
Researchers unlock cancer-causing mechanism of E. coli toxin with synthetic biology approach
Journal Reference:
Zhong-Rui Li, Jie Li, Wenlong Cai, Jennifer Y. H. Lai, Shaun M. K. McKinnie, Wei-Peng Zhang, Bradley S. Moore, Wenjun Zhang, Pei-Yuan Qian. Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 2019; DOI: 10.1038/s41557-019-0317-7
專利和許可
香港分部有1項已申請的國家專利以及1項已申請的國際專利。同時,香港分部亦申請了5項國家專利,3項國際專利,5項美國臨時專利。
國家專利
- "橢圓狀對插型陣列電極及其柔性檢測系統",申請公佈號為CN211955304U。
- "一種將糠醇氧化為二氫吡喃酮類的綠色方法",申請的專利號為202110081888。
- "一種製備氧化吲哚類衍生物的綠色方法",申請的專利號為202110206801。
- "一種綠色的溴化方法",申請的專利號為202110199168.X。
- "作為針對各種神經退行性疾病的潛在治療劑的新化合物",申請的專利號為202111078152.X。
國際專利
- "Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining"。
- “Adenine deficient yeast: A fluorescent biosensor for the detection of Labile Zn (II) in aqueous solution”。
- “Novel compounds as potential therapeutic agents targeting various neurodegenerative diseases”。
美國臨時專利
- "Amperometric electrochemical sensor for the detection of small molecules"。
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"BOC-Butenolide, an antifouling compound that has potent ability to inhibit the settlement of marine invertebrate larvae"。
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“Albofungin and its derivatives specific bind with HIV-1 LTR-III G-quadruplex”。
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“Potent antifouling compounds albofungins target multiple fouling organisms”。
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"Albofungin and its derivatives specifically recognize HIV-1 LTR-III G-quadruplex"。